Protective mechanism of <i>Coprinus comatus</i> polysaccharide on acute alcoholic liver injury in mice，the Metabolomics and Gut Microbiota Investigation

Coprinus comatus polysaccharide (CCP) has significant hepatoprotective effect. To explore mechanism of CCP, the study analyzed preventive effect CCP on acute alcoholic liver injury in mice by histopathological examination and biochemical analysis. Simultaneously, was also conjunction with metabolomics proliferation gut microbiota. The results showed that significantly decreased alanine aminotransferase (ALT), aspartate (AST) triglyceride (TG) levels serum disease (ALD) mice. Histopathological can improve damage. Metabolomics there were differences level metabolites tissue control group, ALD group including taurine, xanthosine, fumaric acid arachidonic acid, among others. Metabolites pathways analysis related to energy metabolism, biosynthesis unsaturated fatty acids, amino acids metabolism lipid metabolism. Additionally, inhibited an increase number Clostridium perfringens, Enterobacteriaceae Enterococcus, a decrease of Lactobacillus Bifidobacterium All these findings suggested treatment reversed phenotype ethanol-induced associated pathways.